Anecdotal Response to Amphotericin in a Patient with Probable Susac Syndrome: Implications in the Pathogenesis

Anecdotal Response to Amphotericin in a Patient with Probable Susac Syndrome: Implications in the Pathogenesis

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Susac syndrome is a rare, probably immune-mediated pure 27 endotheliopathy presenting with encephalopathy, sensorineural hearing loss and retinal arterial occlusions.A 33-year-old female with Susac syndrome was worsening despite high-dose steroids so a brain biopsy was performed which suggested a possible fungal infection.Treatment with amphotericin B resulted in prompt reversal of symptoms and radiological findings, and no further symptoms occurred during 8 years of follow-up.A diagnosis of fungal infection was not confirmed.The etiology of Susac syndrome is unknown and this anecdotal we care vitamin a and d ointment observation suggests that an infectious agent susceptible to amphotericin might have caused or triggered Susac syndrome in this patient.